2-Substituted-pyridazin-3(2H)-ones as Green Electrophilic Agents in Synthesis

Author(s): Gi Hyeon Sung, Bo Ram Kim, Sang-Gyeong Lee, Jeum-Jong Kim, Yong-Jin Yoon.

Journal Name: Current Organic Chemistry

Volume 16 , Issue 7 , 2012

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Pyridazin-3(2H)-ones are inexpensive, stable, and easily prepared heterocycles. Since pyridazin-3(2H)-ones readily form stable anions, and can act as good leaving group. Their utility as synthetic auxiliaries was recently demonstrated by Yoon’s group. 2- Substituted-pyridazin-3(2H)-ones are also useful both the electrophilic agents and equivalents for the functionalization of the electron rich compounds and active methylenes, and synthones. 2-Substituted-pyridazin-3(2H)-ones are novel green agents because that can be recovered quantitatively and recycled. In this review, the preparation and the synthetic application of 2-substituted-pyridazin-3(2H)-ones are described.

Keywords: Acylation, Cyanation, Electrophilic halogenation, N-nitration, Coupling agent, Lactonization, N-arylsulfonation, 2-substitutedpyridazin- 3(2H)-one.

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Article Details

Year: 2012
Page: [852 - 858]
Pages: 7
DOI: 10.2174/138527212800194773
Price: $58

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