Current Nutrition & Food Science

Undurti N. Das  
UND Life Sciences
Shaker Heights
OH 44120
USA

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A Dietary Approach for Treating Dyslipidemia and Hyperglycemia

Author(s): Joseph S. Feuerstein, Leyna T. Bautista, Wendy S. Bjerke.

Abstract:

Background: Elevated LDL cholesterol and impaired fasting glucose are significant risk factors for cardiovascular disease; the most prevalent cause of mortality in the USA.

Many dietary approaches have been examined to help combat these medical problems.

Each type of diet typically places a particular emphasis on the relative proportions of the three macronutrients; fat, carbohydrate and protein.

Methods: We report on a case series of 41 patients who were placed on an 1100 calorie diet reduced in starch and emphasizing lean proteins, mono and polyunsaturated fats and fiber with a unique composition of macronutrients for four months in an effort to improve cholesterol and fasting glucose indices.

Results: 28 of the 41 (68%) patients complied with the protocol over a four-month period.

In the compliant group, statistically significant reduction (p < 0.05) in the following mean variables were seen; Weight (2.3kg), Total Cholesterol 22% (53 mg/dL), LDL 23% (43mg/dL), HDL (4 mg/dL) ,TAG (21mg/dL) and fasting serum glucose (12mg/dL), after 4 months on the dietary regimen.

In the non-compliant/comparison group, statistically significant increase (p < 0.05) in the following variables were seen; Total Cholesterol (24 mg/dL), LDL (14 mg/dL) and TAG (29 mg/dl), at the end of 6 months.

Conclusions: This magnitude of reduction in Total and LDL Cholesterol is significantly greater than that seen in the recent large dietary intervention trials and is comparable to that seen in ‘eco-Atkins’ trial, which was far more restrictive in nature and shorter in duration.

We hypothesize that given the significant reduction in fasting serum glucose and the pre-clinical data showing insulin increasing activity of the HMG CoA reductase enzyme, the underlying mechanism of action for the significant drop in Total and LDL cholesterol may be a reduced serum insulin levels and HMG-CoA reductase activity.

Keywords: Dyslipidemia, hyperglycemia, overweight, reduced starch, reduced saturated fat, diet, high fiber, cholesterol, glucose, cardiovascular diseases

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2011
Page: [271 - 274]
Pages: 4
DOI: 10.2174/1573401311107040271
Price: $58