Novel Isocyanide-Based Three-Component Synthesis of Substituted 9Hfuro[ 2,3-f]chromene-8,9-Dicarboxylates in Water

Author(s): Faramarz Rostami-Charati, Zinatossadat Hossaini, Mohammad A. Khalilzadeh.

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 15 , Issue 5 , 2012

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Three-component reaction of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, dialkyl acetylenedicarboxylates and isocyanides in water was described as efficient and green synthetic procedure for preparation of 9Hfuro[ 2,3-f]chromene-8,9-dicarboxylates in excellent yield. In these reactions, 1-(6-hydroxy-2-isopropenyl-1-benzofuranyl)- 1-ethanone was extracted from rhizomes of Petasites hybridus from northern Iran. The structure of this compound was determined by 1H, 13C-NMR and IR spectroscopy and confirmed by X-ray diffraction analysis. This procedure provides rapid access to novel and diversely substituted 9H-furo[2,3-f]chromene-8,9-dicarboxylate derivatives....

Keywords: 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, chromene, dialkyl acetylenedicarboxylates, isocyanides, Petasites hybridus, three-component reactions, X-ray diffraction

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Article Details

Year: 2012
Page: [433 - 437]
Pages: 5
DOI: 10.2174/138620712800194495
Price: $65

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