Light Fluorous-Tagged Traceless One-Pot Synthesis of Benzimidazoles Facilitated by Microwave Irradiation

Author(s): Chih-Chung Tseng, Cheng-Hsun Tasi, Chung-Ming Sun.

Journal Name: Combinatorial Chemistry & High Throughput Screening

Volume 15 , Issue 5 , 2012

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A novel protocol for rapid assemble of benzimidazole framework has been demonstrated. This method incorporated with light fluorous-tag provides a convenient method for diversification of benzimidazoles and for easy purification via fluorous solid-phase extraction (F-SPE) in a parallel manner. The key transformation of this study involves in situ reduction of aromatic nitro compound, amide formation, cyclization and aromatization promoted by microwave irradiation in a one-pot fashion. The strategy is envisaged to be applied for the establishment of drug-like small molecule libraries for high throughput screening.

Keywords: Benzimidazoles, bioactive heterocycles, fluorous synthesis, F-SPE, microwave chemistry

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Article Details

Year: 2012
Page: [411 - 417]
Pages: 7
DOI: 10.2174/138620712800194521
Price: $58

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