Antibiotics Delay Wound Healing: an Effect Reversed by Co-Administering TLR 7 and 9 Ligands

Author(s): Hiroyasu Ito , Noriho Iida , Dennis M. Klinman .

Journal Name: Current Angiogenesis (Discontinued)

Volume 1 , Issue 1 , 2012

Abstract:

Pathogenic bacteria are recognized by cells expressing Toll-like receptors (TLRs). This interaction initiates an innate immune response that increases host resistance to infection and accelerates wound healing. This work examines whether antibiotics that eliminate bacteria have a detrimental effect on the rate of wound repair. Results indicate that antibiotic treatment i) eliminates bacteria from the skin, ii) reduces wound inflammation (as manifest by decreased expression of IL-1β, CCL2, IFNα and IFNβ mRNA) and thereby iii) delays wound healing. This adverse consequence is corrected by co-administering the TLR9 ligand CpG ODN and/or the TLR7 ligand imiquimod.

Keywords: CpG oligonucleotide, imiquimod, PAMP, TLR, wound healing

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2012
Page: [46 - 51]
Pages: 6
DOI: 10.2174/2211552811201010046

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