Pathogenic bacteria are recognized by cells expressing Toll-like receptors (TLRs). This interaction initiates an
innate immune response that increases host resistance to infection and accelerates wound healing. This work examines
whether antibiotics that eliminate bacteria have a detrimental effect on the rate of wound repair. Results indicate that antibiotic
treatment i) eliminates bacteria from the skin, ii) reduces wound inflammation (as manifest by decreased expression
of IL-1β, CCL2, IFNα and IFNβ mRNA) and thereby iii) delays wound healing. This adverse consequence is corrected by
co-administering the TLR9 ligand CpG ODN and/or the TLR7 ligand imiquimod.
Keywords: CpG oligonucleotide, imiquimod, PAMP, TLR, wound healing
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