Redox Chemistry of Green Tea Polyphenols: Therapeutic Benefits in Neurodegenerative Diseases

Author(s): H. M. Hugel, N. Jackson.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 12 , Issue 5 , 2012

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Abstract:

Evidence for the medicinal and health benefits of polyphenols in green tea for the prevention of chronic diseases such as heart disease, various types of cancer and neurodegenerative diseases is advancing. Their in vivo effectiveness and molecular mechanisms are difficult to elucidate and remain a challenging task. We review the redox responsiveness and amyloid protein perturbation biophysical properties of the major green tea polyphenol constituent (-)- epigallocatechin-3-gallate [EGCG].

Keywords: EGCG, green tea antioxidants, prooxidants, anti-cancer, neuroprotection, Alzheimer’s disease

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Article Details

VOLUME: 12
ISSUE: 5
Year: 2012
Page: [380 - 387]
Pages: 8
DOI: 10.2174/138955712800493906
Price: $58

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