Anti-Infective Agents

Anti-Infective Agents in Medicinal Chemistry


Synthesis and Characterization of Some New Thiazole based Thiazolidinone Derivatives as Potent Antimicrobial and Antimycobacterial Agents

Author(s): N. C. Desai, K. M. Rajpara, V. V. Joshi, H. V. Vaghani, H. M. Satodiya.


The present article deals with the synthesis, antimicrobial and antimycobacterial activities of a novel series of N-(5-(2-(5-(arylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)benzamides (6a-o). The structures of these compounds have been elucidated by spectra (IR, 1H NMR, 13C NMR, mass spectra). All the synthesized compounds are screened for in vitro antibacterial activity against Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. These compounds are also tested for their inhibitory action against three strains of fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus). Same synthesized compounds are also tested for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv.

Keywords: Antibacterial activity, antifungal activity, antimycobacterial activity, knoevengel reaction, MIC, thiazole, thiazolidinone

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Article Details

Year: 2012
Page: [75 - 86]
Pages: 12
DOI: 10.2174/2211362611208020075
Price: $58