Synthesis and Characterization of Some New Thiazole based Thiazolidinone Derivatives as Potent Antimicrobial and Antimycobacterial Agents
N. C. Desai,
K. M. Rajpara,
V. V. Joshi,
H. V. Vaghani,
H. M. Satodiya.
The present article deals with the synthesis, antimicrobial and antimycobacterial activities of a novel series of
The structures of these compounds have been elucidated by spectra (IR, 1H NMR, 13C NMR, mass spectra). All the synthesized
compounds are screened for in vitro antibacterial activity against Gram-positive (Staphylococcus aureus, Streptococcus
pyogenes) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. These compounds are also
tested for their inhibitory action against three strains of fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus).
Same synthesized compounds are also tested for their in vitro antimycobacterial activity against Mycobacterium
Keywords: Antibacterial activity, antifungal activity, antimycobacterial activity, knoevengel reaction, MIC, thiazole,
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