Cognitive, Psychological and Psychiatric Effects of Ionizing Radiation Exposure

Author(s): D. Marazziti, S. Baroni, M. Catena-Dell'Osso, E. Schiavi, D. Ceresoli, C. Conversano, L. Dell'Osso, E. Picano.

Journal Name: Current Medicinal Chemistry

Volume 19 , Issue 12 , 2012

Abstract:

Radiation exposure leads to an increased risk for cancer and, possibly, additional ill-defined non-cancer risk, including atherosclerotic, cardiovascular, cerebro-vascular and neurodegenerative effects. Studies of brain irradiation in animals and humans provide evidence of apoptosis, neuro-inflammation, loss of oligo-dendrocytes precursors and myelin sheaths, and irreversible damage to the neural stem compartment with long-term impairment of adult neurogenesis.

With the present paper we aim to present a comprehensive review on brain effects of radiation exposure, with a special focus on its impact on cognitive processes and psychological functions, as well as on their possible role in the pathophysiology of different psychiatric disorders.

Keywords: Ionizing radiation, cognitive processes, memory, neurogenesisi, hippocampus, psychiatric disorders

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Article Details

VOLUME: 19
ISSUE: 12
Year: 2012
Page: [1864 - 1869]
Pages: 6
DOI: 10.2174/092986712800099776
Price: $58

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