Abstract
Fatty acid synthesis is a coordinated process involving multiple enzymes. Overexpression of some of these enzymes plays important roles in tumor growth and development. Therefore, these enzymes are attractive targets for cancer therapies. Antisense agents provide highly specific inhibition of the expression of target genes and thus have served as powerful tools for gene functional studies and potential therapeutic agents for cancers. This article reviews different types of antisense agents and their applications in the modulation of fatty acid synthesis. Patents of antisense agents targeting fatty acid synthetic enzymes are introduced. In addition, miR-122 has been shown to regulate the expression of fatty acid synthetic enzymes, and thus antisense agent patents that inhibit miR-122 expression are also discussed.
Keywords: Acetyl-CoA carboxylase, antisense nucleotide, ATP citrate lyase, fatty acid synthesis, fatty acid synthetase, lipogenesis, miRNA-122, siRNAs
Recent Patents on Anti-Cancer Drug Discovery
Title:Antisense Technologies Targeting Fatty Acid Synthetic Enzymes
Volume: 7 Issue: 2
Author(s): Jinshun Lin, Feng Liu and Yuyang Jiang
Affiliation:
Keywords: Acetyl-CoA carboxylase, antisense nucleotide, ATP citrate lyase, fatty acid synthesis, fatty acid synthetase, lipogenesis, miRNA-122, siRNAs
Abstract: Fatty acid synthesis is a coordinated process involving multiple enzymes. Overexpression of some of these enzymes plays important roles in tumor growth and development. Therefore, these enzymes are attractive targets for cancer therapies. Antisense agents provide highly specific inhibition of the expression of target genes and thus have served as powerful tools for gene functional studies and potential therapeutic agents for cancers. This article reviews different types of antisense agents and their applications in the modulation of fatty acid synthesis. Patents of antisense agents targeting fatty acid synthetic enzymes are introduced. In addition, miR-122 has been shown to regulate the expression of fatty acid synthetic enzymes, and thus antisense agent patents that inhibit miR-122 expression are also discussed.
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Cite this article as:
Lin Jinshun, Liu Feng and Jiang Yuyang, Antisense Technologies Targeting Fatty Acid Synthetic Enzymes, Recent Patents on Anti-Cancer Drug Discovery 2012; 7 (2) . https://dx.doi.org/10.2174/157489212799972945
DOI https://dx.doi.org/10.2174/157489212799972945 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
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In recent years, traditional cancer treatments, such as surgery, chemotherapy, and radiation treatment, etc., may damage the pathological tissue and normal cells. The ideal tumor treatment should be noninvasive, eliminating the primary tumor, making the body produce systemic tumor-specific immunity, eliminating metastases, and having less /no side effects. Recent Patents ...read more
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