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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Luminescent G-quadruplex Probes

Author(s): Dik-Lung Ma, Daniel Shiu-Hin Chan, Hui Yang, Hong-Zhang He and Chung-Hang Leung

Volume 18, Issue 14, 2012

Page: [2058 - 2075] Pages: 18

DOI: 10.2174/138161212799958314

Price: $65

Abstract

G-quadruplexes have found increasing potential in applications such as molecular therapeutics, diagnostics, and sensing. As a consequence, small molecules capable of selectively detecting G-quadruplexes have received significant attention in recent literature. Our review here addresses representative advances in the development of luminescent G-quadruplex probes and highlights their potential applications in sensing and imaging.

Keywords: G-quadruplex, DNA, small molecules, luminescent probes, detection, diagnostics, telomere, topologies, propeller, emission


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