Patented Routes for the Preparation of the Morphinan Derivatives Hydromorphone and Hydrocodone Via Catalytic Isomerization
Alba E. Diaz-Alvarez and Victorio Cadierno
Affiliation: Departamento de Quimica Organica e Inorganica, Facultad de Quimica, Universidad de Oviedo, Julian Claveria 8, E-33006 Oviedo, Spain.
Keywords: Codeine, hydrocodone, hydromorphone, morphinan derivatives, morphine, redox isomerization of allylic alcohols, transition-metal complexes.
Hydromorphone and hydrocodone are widely used narcotic analgesics. In this mini-review article, processes
for the preparation of these semi-synthetic opioids from the naturally occurring opiates morphine and codeine, respectively,
via catalytic isomerization of the allylic alcohol unit of the latter are discussed. Relevant patents in the field are
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