Application of Chirally Modified Nickel Catalysts for Production of Optically Active Compounds
Tsutomu Osawa and Victor Borovkov
Affiliation: Graduate School of Science and Engineering for Research, University of Toyama, Gofuku, Toyama 930- 8555, Japan.
Keywords: Asymmetric synthesis, chiral catalysts, chiral compounds, enantio-differentiating hydrogenation, methyl acetoacetate, modified nickel catalyst, nickel powder, Raney nickel, tartaric acid.
The major patents concerning chirally modified nickel catalysts by enantiomerically pure tartaric acid are comprehensively
surveyed. The methods of catalyst's preparation for attaining a high enantioselectivity and the synthetic
routes for obtaining optically active compounds by using these tartaric acid-modified nickel catalysts are summarized. A
recently claimed patent dealing with the robust chiral nickel catalyst, which exhibits an exceptionally high stability after
preparation is also introduced.
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