Application of Chirally Modified Nickel Catalysts for Production of Optically Active Compounds
Tsutomu Osawa and Victor Borovkov
Affiliation: Graduate School of Science and Engineering for Research, University of Toyama, Gofuku, Toyama 930- 8555, Japan.
The major patents concerning chirally modified nickel catalysts by enantiomerically pure tartaric acid are comprehensively
surveyed. The methods of catalyst's preparation for attaining a high enantioselectivity and the synthetic
routes for obtaining optically active compounds by using these tartaric acid-modified nickel catalysts are summarized. A
recently claimed patent dealing with the robust chiral nickel catalyst, which exhibits an exceptionally high stability after
preparation is also introduced.
Keywords: Asymmetric synthesis, chiral catalysts, chiral compounds, enantio-differentiating hydrogenation, methyl acetoacetate, modified nickel catalyst, nickel powder, Raney nickel, tartaric acid.
Rights & PermissionsPrintExport