Cell-Based Therapy to Promote Angiogenesis in the Brain Following Ischemic Damage

Author(s): Masahiro Uemura , Yukiko Kasahara , Kazuyuki Nagatsuka , Akihiko Taguchi .

Journal Name: Current Vascular Pharmacology

Volume 10 , Issue 3 , 2012

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Abstract:

Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.

Keywords: Angiogenesis, neurogenesis, stroke, neural stem cells, CD34-positive cells

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2012
Page: [285 - 288]
Pages: 4
DOI: 10.2174/157016112799959369
Price: $58

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