Resveratrol is a polyphenol that among other sources occurs in grapes and for this reason, red wines also contain considerable
amounts of this compound. Resveratrol is thought to be responsible for the ‘‘French Paradox’’ which associates red wine consumption to
the low incidence of cardiovascular diseases. The interest in resveratrol has increased due to its pharmacological effects that include
cardio and neuroprotection and several other benefic actions (e.g. antioxidant, anti-inflammatory, anti-carcinogenic and anti-aging).
Despite the therapeutic effects of resveratrol, its pharmacokinetic properties are not favorable since this compound has poor
bioavailability being rapidly and extensively metabolized and excreted. To overcome this problem, drug delivery systems have been
developed to protect and stabilize resveratrol and to enhance its bioavailability. Herein is presented an up-to-date revision covering the
literature reported for nano and microformulations for resveratrol encapsulation that include liposomes, polymeric nanoparticles, solid
lipid nanoparticles, lipospheres, cyclodextrins, polymeric microspheres, yeast cells carriers and calcium or zinc pectinate beads.
Regarding the interaction of resveratrol with cell membranes, only few studies have been published so far. However, it is believed that
this interaction can be implied in the biological activities of resveratrol since transmembranar proteins are one of its cellular targets.
Indeed, resveratrol presents the capacity to modulate the membrane organization which may consequently affect the protein functionality.
Therefore, the intracellular effects of resveratrol and the effects of this compound at the membrane level were also revised since their
knowledge is essential for understanding the pharmacological and therapeutic activities of this bioactive compound.