Insulin- and Growth Factor-Resistance Impairs Vascular Regeneration in Diabetes Mellitus
Richard M. Cubbon, Noman Ali, Anshu Sengupta and Mark T. Kearney
Pages 271-284 (14)
Diabetes and pre-diabetes are major contributors to cardiovascular mortality and morbidity. Insulin resistance is a
key pathophysiological determinant of the metabolic and vascular abnormalities noted in these disorders. Ineffective vascular
repair is likely to be an important contributor to the development of endothelial dysfunction, and subsequently atherosclerosis,
in patients with diabetes. Beyond the systemic effects of the insulin resistant phenotype, including factors such as dysglycaemia
and inflammation, cellular insulin resistance is emerging as an important factor in diabetic vascular disease. Disordered
signal transduction via the PI3-kinase/Akt and MAP-kinase cascades is a hallmark of cellular insulin resistance, and such
changes have been linked with both endothelial dysfunction and impaired angiogenesis. In this review we highlight the importance
of insulin resistance to vascular repair and regeneration, discuss important cross-talk between the intracellular signalling
of insulin and key pro-angiogenic molecules, and link these concepts to common patterns of vascular disease.
Angiogenesis, diabetes, insulin resistance, insulin-like growth factor-1, progenitor, vascular
Division of Cardiovascular and Diabetes Research, Multidisciplinary Cardiovascular Research Centre, LIGHT Laboratories, The University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK.