Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment

Author(s): Maria Volkova, Raymond Russell.

Journal Name: Current Cardiology Reviews

Volume 7 , Issue 4 , 2011

Abstract:

Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.

Keywords: Left ventricular dysfunction, doxorubicin, oxidant stress.

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Article Details

VOLUME: 7
ISSUE: 4
Year: 2011
Page: [214 - 220]
Pages: 7
DOI: 10.2174/157340311799960645
Price: $58

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