One Pot Multi-Component Synthesis of N-Substituted Decahydroacridine- 1, 8-Diones Catalyzed by MoO3/SiO2 as an Efficient and Reusable Heterogeneous Catalyst

Author(s): Vijay S. Patil, Kamalakar P. Nandre, Mohan B. Kalyankar, Santosh V. Nalage, Namdev V. Ghule, Sidhanath V. Bhosale, Sheshanath V. Bhosale.

Journal Name: Current Catalysis

Volume 1 , Issue 1 , 2012

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Abstract:

A simple, efficient and ecofriendly one pot synthesis protocol has been developed for the synthesis of N-substituted decahydroacridine-1,8-diones by using an efficient and recyclable solid acidic silica supported MoO3/SiO2 catalyst from a condensation of aldehyde, amine and cyclic 1,3-diketone in THF. The reaction using MoO3/SiO2 catalyst was carried out under mild condition with very high yields up to 92%. The present approach of this methodology offers several advantages such as shorter reaction times, good yields, low cost, environmentally benign, milder reaction conditions, easy recovery of catalyst and reusability.

Keywords: N-Substituted decahydroacridine-1, 8-dione, MoO3/SiO2, solid acid catalyst, one pot multi-component, Heterogeneous Catalyst, organic synthesis, pharmaceutical chemistry, raw materials, non-toxic reagents, solvents, catalysts, medicinal chemistry, material science, antimalerial, anti-inflammatory

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2012
Page: [73 - 77]
Pages: 5
DOI: 10.2174/2211544711201010073

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