A simple, efficient and ecofriendly one pot synthesis protocol has been developed for the synthesis of N-substituted decahydroacridine-1,8-diones by using an efficient and recyclable solid acidic silica supported MoO3/SiO2 catalyst from a condensation of aldehyde, amine and cyclic 1,3-diketone in THF. The reaction using MoO3/SiO2 catalyst was carried out under mild condition with very high yields up to 92%. The present approach of this methodology offers several advantages such as shorter reaction times, good yields, low cost, environmentally benign, milder reaction conditions, easy recovery of catalyst and reusability.
Keywords: N-Substituted decahydroacridine-1, 8-dione, MoO3/SiO2, solid acid catalyst, one pot multi-component, Heterogeneous Catalyst, organic synthesis, pharmaceutical chemistry, raw materials, non-toxic reagents, solvents, catalysts, medicinal chemistry, material science, antimalerial, anti-inflammatory
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