H6P2W12O62.24H2O Supported on Silica: A Powerful and Reusable Catalyst for the Synthesis of 4-Arylidene-2-Phenyl-5(4)-Oxazolones (Azlactones)

Author(s): Diego M. Ruiz, Graciela T. Baronetti, Horacio J. Thomas, Gustavo P. Romanelli.

Journal Name:Current Catalysis

Volume 1 , Issue 1 , 2012

Abstract:

A simple, efficient and ecofriendly one-pot synthesis protocol has been developed for the synthesis of 4- arylidene-2-phenyl-5(4)-oxazolones (azlactones) by using an efficient and recyclable solid acid silica-supported H6P2W18O62.24H2O catalyst from a condensation of aldehydes, hippuric acid and acetic anhydride in toluene. The reaction using 0.4WDSiO2 catalyst was carried out under mild conditions with very high yields of up to 89%-93%. The heterogeneous reaction conditions provided a very simple, environmentally friendly, clean, economical and selective protocol for the preparation of these compounds. The catalyst is easily recycled and reused without loss of the catalytic activity.

Keywords: Heterogeneous catalysis, Wells-Dawson heteropolyacid, Green Chemistry, 4-arylidene-2-phenyl-5(4)-oxazolones, Azlactones, chemistry, homogeneous, heteropolyacids, organic chemists, bioactive compounds, biological sciences, pharmaceutical science, asymmetric synthesis, amino acids

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Article Details

VOLUME: 1
ISSUE: 1
Year: 2012
Page: [67 - 72]
Pages: 6
DOI: 10.2174/2211544711201010067