Effects of Platinum Nanoparticles on Apoptosis

Author(s): Yoko Yoshihisa, Mariame Ali Hassan, Takashi Kondo, Tadamichi Shimizu.

Journal Name: Recent Patents on Nanomedicine (Discontinued)

Volume 1 , Issue 2 , 2011

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Abstract:

Platinum nanoparticles (nano-Pts) scavenge superoxides and peroxides indicating that they can act as superoxide dismutase (SOD)/catalase mimetics. This could be useful for protection against and/or amelioration of oxidative stress-associated pathologies. Recent studies investigated the effects of poly acrylic acid-capped nano-Pts on hyperthermia (HT) and ultraviolet (UV)-induced apoptosis and the underlying molecular mechanisms in human lymphoma cells and keratinocytes, respectively. The reports showed that nano-Pts resulted in HT-desensitization in lymphoma cells where the signaling pathways involved in apoptosis were inhibited by nano-Pts. On the other hand, nano- Pts effectively protected against UV-induced inflammation in keratinocytes by decreasing reactive oxygen species (ROS) production and inhibiting apoptosis. This chapter reviews the latest findings on the effects of nano-Pts on HT- and UVinduced apoptosis and also discusses some recent patents related to this field.

Keywords: platinum nanoparticles, heat, ultraviolet, apoptosis, ROS, inflammation, catalase mimetics, hyperthermia, human lymphoma cells, UV-induced inflammation, Nanotechnology, pulmonary inflammation, tumor tissues, heat shock treatment, cytochrome

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Article Details

VOLUME: 1
ISSUE: 2
Year: 2011
Page: [162 - 165]
Pages: 4
DOI: 10.2174/1877912311101020162
Price: $58

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