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The Natural Products Journal
ISSN (Print): 2210-3155
ISSN (Online): 2210-3163
VOLUME: 1
ISSUE: 1
DOI: 10.2174/2210315511101010040









Comparative Study of the Antimicrobial Activities and Mammalian Cytotoxicity of 10 Fatty Acid-Rich Oils and Fats from Animal and Vegetable

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Author(s): Luciano P. Silva, Graziella A. Joanitti, Jose Roberto S. A. Leite and Ricardo B. Azevedo
Pages 40-46 (7)
Abstract:
The antibacterial, antifungal, and hemolytic activities of bullfrog oil, fish oil, bovine milk fat, pork fat, beef fat, canola oil, dende oil, sunflower oil, olive oil, and soybean oil were assessed. In addition, the effects of these oils and fats on cell viability and phagocytic capacity of macrophages were determined. Bullfrog, canola, fish, dende, olive, and sunflower oils and bovine milk fat displayed different ranges of antibacterial activity. Bullfrog and canola oils also displayed inhibitory effects against Candida species. Tested in vitro cytotoxicity indicated that dende, sunflower, soybean, and fish oils decreased macrophages viability, and that dende, bullfrog, and fish oils displayed activities against red blood cells. In addition, dende oil decreased, and canola, olive, bullfrog, and fish oils increased the phagocytic capacity of macrophages. Further exploration of the potential use of some of these oils and fats in microorganisms control appear warranted, particularly in formulation of antimicrobial products.
Keywords:
Fatty acids, antimicrobial, antibacterial, antifungal, hemolytic, bullfrog oil, fish oil, bovine milk fat, pork fat, beef fat
Affiliation:
Embrapa Recursos Geneticos e Biotecnologia, Nucleo Tematico de Biotecnologia, Laboratorio de Espectrometria de Massa, Parque Estacao Biologica Final W5 Norte, Asa Norte, Brasilia, 70770-917, DF, Brazil.