Current Aging Science

Prof. Debomoy K. Lahiri
Department of Psychiatry Indiana University School of Medicine
Indianapolis, IN
USA

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Mitochondria, Cellular Stress Resistance, Somatic Cell Depletion and Lifespan

Author(s): Ellen L. Robb, Melissa M. Page and Jeffrey A. Stuart

Affiliation: Department of Biological Sciences, Brock University, St. Catharines, Ontario, L2S 3A1, Canada.

Keywords: Mitochondria, lifespan, reactive oxygen species, superoxide dismutase, glutathione peroxidase, mtDNA, base excision repair, mutation

Abstract:

The causes of aging and determinants of maximum lifespan in animal species are multifaceted and complex. However, a wealth of experimental data suggests that mitochondria are involved both in the aging process and in regulating lifespan. Here we outline a somatic cell depletion (SCD) model to account for correlations between: (1) mitochondrial reactive oxygen species and lifespan; (2) mitochondrial antioxidant enzymes and lifespan; (3) mitochondrial DNA mutation and lifespan and (4) cellular stress resistance and lifespan. We examine the available data from within the framework of the SCD model, in which mitochondrial dysfunction leading to cell death and gradual loss of essential somatic cells eventually contributes to the decline in physiological performance that limits lifespan. This model is useful in explaining many of the mitochondrial manipulations that alter maximum lifespan in a variety of animal species; however, there are a number of caveats and critical experiments outstanding, and these are outlined in this review.

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Article Details

VOLUME: 2
ISSUE: 1
Page: [12 - 27]
Pages: 16
DOI: 10.2174/1874609810902010012