Abstract
The left ventricle thickness is a limiting factor of optimal heart size and strength. Due to disappearance of all the features compromising left ventricular compliance, mammalian heart has decreased vascular density and coronary vessel diameter and it requires sufficient diastolic aortic pressure for the left ventricle perfusion. Atrial muscle and the right ventricle are perfused during the entire heart cycle. The systolic pressure in the left ventricle forces blood vessels in the muscle wall to collapse, particularly in the subendocardial muscle layer. This makes the most active part of the heart prone to hypoxia. Optimal perfusion of the left ventricle wall requires sufficient aortic pressure during diastole, making individuals with higher diastolic pressures advantageous, in situations requiring combination of increased heart rate and output. Described mechanisms might have contributed to the hereditary quality of age-related hypertension in humans.
Keywords: Hypertension, diastolic aortic pressure, subendocardial muscle, Ageing, Heart and Aorta
Current Aging Science
Title: Possible Links of Age Related Hypertension and Evolution Imposed Features of Heart and Aorta
Volume: 1 Issue: 3
Author(s): Sven Kurbel
Affiliation:
Keywords: Hypertension, diastolic aortic pressure, subendocardial muscle, Ageing, Heart and Aorta
Abstract: The left ventricle thickness is a limiting factor of optimal heart size and strength. Due to disappearance of all the features compromising left ventricular compliance, mammalian heart has decreased vascular density and coronary vessel diameter and it requires sufficient diastolic aortic pressure for the left ventricle perfusion. Atrial muscle and the right ventricle are perfused during the entire heart cycle. The systolic pressure in the left ventricle forces blood vessels in the muscle wall to collapse, particularly in the subendocardial muscle layer. This makes the most active part of the heart prone to hypoxia. Optimal perfusion of the left ventricle wall requires sufficient aortic pressure during diastole, making individuals with higher diastolic pressures advantageous, in situations requiring combination of increased heart rate and output. Described mechanisms might have contributed to the hereditary quality of age-related hypertension in humans.
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Cite this article as:
Kurbel Sven, Possible Links of Age Related Hypertension and Evolution Imposed Features of Heart and Aorta, Current Aging Science 2008; 1 (3) . https://dx.doi.org/10.2174/1874609810801030166
DOI https://dx.doi.org/10.2174/1874609810801030166 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
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