Recent Patents on Oligonucleotide Synthesis and Gene Synthesis
Tingsheng Yu, Xiao Bao, Wenxian Piao, Jingli Peng, Wei Li, Cui Yang, Meng Xing, Yiliu Zhang, Jinhuan Qi, Lei Xu, Li Xu and Qiuyun Liu
Affiliation: School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, P. R. China.
Keywords: Oligonucleotide synthesis, gene synthesis, miniaturization, multiplexing, microfluidic processing, microchip, Chloral-Free Dichloroacetic Acid in, Activators for Oligonucleotide, Universal Supports for Oligonucleotide Synthesis, Multiplexing for Polymer Synthesis, DNA-Polymerase-based Synthesis Reactions, Transcriptional Regulatory Sites, Nucleic Acid Molecules, Genes and Genomes, Sequence-Verified Nucleic Acids
Gene synthesis is an emerging field which has widespread implications in synthetic biology and molecular biology. The field is constantly evolving which has led to key advances in oligonucleotide synthesis and gene synthesis technologies, with simplicity, cost effectiveness and high throughput. The miniaturization, multiplexing, microfluidic processing and the integrated microchip engineering will drive down cost and increase productivity without compromising DNA synthesis fidelity, whereas the gigantic amount of genome information provides infinite source of DNA elements and genes as raw material for synthetic biology. This article describes some of the recent patents on oligonucleotide synthesis and gene synthesis.
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