Gene Delivery System: A Developing Arena of Study for the New Era of Medicine
Saifur Rahman Khan, Advaita Ganguly, Ravindra B. Malabadi, Hoon H. Sunwoo and Mavanur R. Suresh
Affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, 11304-89 Avenue, Edmonton, T6G 2N8, Canada.
Keywords: Nanoparticles, plasmid DNA, transfection, targeting, vectors, vaccines, GENE DELIVERY, PLASMID BASED GENE EXPRESSION, Recombinant Adenovirus vector, Recombinant Retrovirus Vector, Recombinant Herpes Simplex Virus Vector, VIRUS INDEPENDENT GENE DELIVERY, HYBRID VECTORS, X-SCID
Gene therapy concept has been being overcome massive challenges from 1972 in ethical, socio-economical and developmental issues. In this review, we have attempted to go through almost all the arenas and described in a methodical way that reflects not only the initial ethical and scientific thoughts but also adorned a solid depiction of gene therapy related physico-chemical barriers, approaches and strategies till to date.
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