Journal Image
Current Drug Abuse Reviews
ISSN (Print): 1874-4737
ISSN (Online): 1874-4745
DOI: 10.2174/1874473711104040261      Price:  $58

A Review of Preclinical Research Demonstrating that Drug and Non-Drug ReinforcersDifferentially Affect Behavior

Author(s): David N. Kearns, Maria A. Gomez-Serrano and Brendan J. Tunstall
Pages 261-269 (9)
This review describes and summarizes current preclinical research revealing important differences between drug and non-drug reinforcers in terms of their effects on behavior. Despite research showing that drugs are not especially strong reinforcers in animals, a number of other behavioral differences potentially relevant to addiction have been reported in studies that have compared drug and non-drug reinforcers. Several of these effects appear only after long-term access to drugs. These include an escalation of drug intake, an increased persistence in responding for the drug, and a decreased sensitivity to the effects of punishers or other suppressors of drug seeking. Further differences between drug and non-drug reinforcers include the effects that reinforcer-paired stimuli have on behavior. Drug cues, as compared to food cues, have been shown to exert greater control over reinforcer-seeking behavior after periods of abstinence. Similarly, behavior previously reinforced by drugs, but not food, has been shown to be susceptible to stress-induced reinstatement after extinction. The behavioral differences between drug and non-drug reinforcers reviewed here may identify special features of drugs that lead to addiction.
Animal models of drug abuse, addiction, reinforcer, reward, drug self-administration, cocaine, food, Preclinical, sensitivity, Escalation
Psychology Department, American University, Washington, DC 20016, USA.