Abstract
The efficacy of current anti-cancer multimodal therapeutic strategies in gliomas is limited by the lack of specific therapies against malignant cells and the prognosis in patients affected by cerebral gliomas remains very unfavorable. Glial tumors seem to be able to create a favorable environment for the invasion of neoplastic cells when they combine with the extracellular matrix through the up-regulation of crucial pathways such as angiogenesis and invasion. The major problem in brain drug delivery is the presence of the blood brain barrier which limits the delivery of many chemotherapeutic agents and other kinds of therapeutic molecules. This event often contributes to the failure of the treatment. Nanoparticle systems can represent ideal devices for delivery of specific compounds to brain tumors across the blood brain barrier. The specificity of hybridization makes antisense method an interesting strategy to selectively modulate the expression of genes involved in tumorigenesis. In this review we will focus on the mechanisms of angiogenesis into gliomas, their importance into tumor progression and the possibilities to block these mechanisms with new nanoparticle-based therapeutic strategies. We will also report the results of preclinical and/or clinical studies that adopt nanoparticle-based antiangiogenic therapeutic approach in cerebral gliomas, considering also some patents deal with antiangiogenic strategy.
Keywords: Antisense therapy, blood brain barrier, angiogenesis, gliomas treatment, nanoparticle systems, Cerebral Drug-Delivery, Antiangiogenic, Glioblastoma multiforme, anaplastic astrocytomas, Malignant gliomas, infiltrate brain tissue, gliomagenesis, proangiogenic, degree of malignancy
Recent Patents on Nanotechnology
Title: Nanoparticle-based Cerebral Drug-Delivery Systems and Antiangiogenic Approach in Gliomas Treatment
Volume: 5 Issue: 3
Author(s): Giuseppe Raudino, Mariella Caffo, Gerardo Caruso, Concetta Alafaci and Francesco Tomasello
Affiliation:
Keywords: Antisense therapy, blood brain barrier, angiogenesis, gliomas treatment, nanoparticle systems, Cerebral Drug-Delivery, Antiangiogenic, Glioblastoma multiforme, anaplastic astrocytomas, Malignant gliomas, infiltrate brain tissue, gliomagenesis, proangiogenic, degree of malignancy
Abstract: The efficacy of current anti-cancer multimodal therapeutic strategies in gliomas is limited by the lack of specific therapies against malignant cells and the prognosis in patients affected by cerebral gliomas remains very unfavorable. Glial tumors seem to be able to create a favorable environment for the invasion of neoplastic cells when they combine with the extracellular matrix through the up-regulation of crucial pathways such as angiogenesis and invasion. The major problem in brain drug delivery is the presence of the blood brain barrier which limits the delivery of many chemotherapeutic agents and other kinds of therapeutic molecules. This event often contributes to the failure of the treatment. Nanoparticle systems can represent ideal devices for delivery of specific compounds to brain tumors across the blood brain barrier. The specificity of hybridization makes antisense method an interesting strategy to selectively modulate the expression of genes involved in tumorigenesis. In this review we will focus on the mechanisms of angiogenesis into gliomas, their importance into tumor progression and the possibilities to block these mechanisms with new nanoparticle-based therapeutic strategies. We will also report the results of preclinical and/or clinical studies that adopt nanoparticle-based antiangiogenic therapeutic approach in cerebral gliomas, considering also some patents deal with antiangiogenic strategy.
Export Options
About this article
Cite this article as:
Raudino Giuseppe, Caffo Mariella, Caruso Gerardo, Alafaci Concetta and Tomasello Francesco, Nanoparticle-based Cerebral Drug-Delivery Systems and Antiangiogenic Approach in Gliomas Treatment, Recent Patents on Nanotechnology 2011; 5 (3) . https://dx.doi.org/10.2174/1872210511105030239
DOI https://dx.doi.org/10.2174/1872210511105030239 |
Print ISSN 1872-2105 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4020 |
Call for Papers in Thematic Issues
Advances in Vanadium and Titanium Resources for High-performance Materials via Nanostructuring and Nanoengineering (updated BMS-NANOTEC-2023-HT-31)
Vanadium and titanium-based materials are ideal candidates for structural and functional materials in aerospace, biomedical engineering, optics, catalysis, energy storage and conversion etc. Vanadium/titanium-based alloys, compounds and materials have a large family with different chemical compositions, dimensions, structures/morphologies, and chemical/physical/mechanical properties, which provides huge opportunities for the development of emerging ...read more
Green Nanotechnology and Nanomaterials for a Sustainable Environment
Green nanotechnology (GN) might wind up being the most efficient platform for achieving the goals of the 2030 Agenda. The goal of GN is to create goods and procedures that are secure, energy-efficient, waste-free, and emit fewer greenhouse gases. Such goods and procedures use renewable resources, and/or their environmental impact ...read more
Nano-coatings and Nanoscale Composites for Hazardous Environments
Automobile, defence, and aerospace sectors need lightweight material for fuel efficiency and lower emissions. Often these materials are added with nanoscale reinforcements or have to be coated with nanomaterials to improve the scratch resistance, self-healing behaviour and corrosion and wear resistance and are all much needed for hazardous environments without ...read more
NANOSTRUCTURED NEUROMORPHIC DEVICES: TOWARDS IN MATERIA COMPUTING
The efforts pursued in the last decade to build up brain-inspired systems with electronic hardware solutions to solve complex data processing tasks, have leaded to the development of a new generation of devices, as memristor crossbar arrays, and their different applications became more and more reliable. One of the basic ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
From Peptides to Small Molecules: An Intriguing but Intricated Way to New Drugs
Current Medicinal Chemistry Optical and Multimodal Peptide-Based Probes for In Vivo Molecular Imaging
Anti-Cancer Agents in Medicinal Chemistry Fluorescein-labeled Bacitracin and Daptomycin Conjugates: Synthesis, Fluorescence Imaging and Evaluation
Medicinal Chemistry Anti-inflammatory Property of AMP-activated Protein Kinase
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Targeting Mitochondria in Fighting Cancer
Current Pharmaceutical Design The Neurotrophic and Antiangiogenic Functions of PEDF: A Reflection of its Variable Phosphorylation States
Current Genomics Regulation of Cell Migration and Invasion by Specific Modules of uPA: Mechanistic Insights and Specific Inhibitors
Current Drug Targets Ion Transporters in Brain Tumors
Current Medicinal Chemistry Adult Neural Stem Cell Therapy: Expansion In Vitro, Tracking In Vivo and Clinical Transplantation
Current Drug Targets Glimpse into the Cellular Internalization and Intracellular Trafficking of Lipid- Based Nanoparticles in Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry AAVs Anatomy: Roadmap for Optimizing Vectors for Translational Success
Current Gene Therapy Editorial (Thematic Issue: Mechanisms of Cancer Stem Cell Resistance to Chemotherapy)
Current Signal Transduction Therapy Co-delivery Strategies Based on Multifunctional Nanocarriers for Cancer Therapy
Current Drug Metabolism Nano-Carriers of Combination Tumor Physical Stimuli-Responsive Therapies
Current Drug Delivery Protein Extracts from Somaclonal Mistletoe (Viscum Album L.) Callus with Increased Tumor Cytotoxic Activity in Vitro
Current Bioactive Compounds Every Cloud Has a Silver Lining: Proneurogenic Effects of Aβ Oligomers and HMGB-1 via Activation of the RAGE-NF-κB Axis
CNS & Neurological Disorders - Drug Targets Meet the Editorial Board:
Current Alzheimer Research Small Molecules for Immunomodulation in Cancer: A Review
Anti-Cancer Agents in Medicinal Chemistry Brain Tumour Stem Cells: Implications for Cancer Therapy and Regenerative Medicine
Current Stem Cell Research & Therapy The Heat Shock Protein 90 Chaperone Complex: An Evolving Therapeutic Target
Current Cancer Drug Targets