Role of Beta2 Agonists in Respiratory Medicine with Particular Attention to Novel Patents and Effects on Endocrine System and Immune Response
Nancy E. Larocca, Dolores Moreno, Jenny V. Garmendia and Juan B. De Sanctis
Affiliation: Instituto de Inmunologia,Facultad de Medicina, Universidad Central de Venezuela, Apartado 50109,Caracas 1050-A, Venezuela.
Keywords: Adrenergic receptor agonists, lymphocytes, macrophages, asthma, β2 adrenergic receptor, COPD, genetic polymorphism, immune response, neutrophils, LABA
Beta adrenergic receptors are very important in respiratory medicine. Traditionally, the stimulation of beta adrenergic receptors by beta2-agonists is commonly used for giving bronchodilation in chronic airflow obstruction However; the wide distribution of these receptors in cells and tissues other than airway smooth muscle suggests that beta agonists should offer other beneficial effects in respiratory disease. Recent studies have shown the importance of these receptors in the modulation of endocrine and immune system that affect respiratory function and may decrease therapy effectiveness in asthma and chronic obstructive pulmonary disease. New patented compound and uses have provided new insights in future therapeutics of respiratory diseases in which genetic, endocrine and immune response should be considered.
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