Toxicity and Relative Biological Effectiveness of Alpha Emitting Radioimmunoconjugates

Author(s): Jostein Dahle, Nasir Abbas, Oyvind S. Bruland, Roy H. Larsen.

Journal Name: Current Radiopharmaceuticals

Volume 4 , Issue 4 , 2011

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Abstract:

Radioimmunotherapy based on α-particle emitters has excellent properties as a treatment against micrometastatic and disseminated cancers because of the short path length (50 – 80 μm) and high linear energy transfer (∼ 100 keV/ μm). Alpha-particles produce clustered DNA double-strand breaks and highly reactive hydroxyl radicals when hitting biological tissue. Hence, targeted α-particle therapy offers the potential of selective tumor cell killing with low damage to surrounding normal tissue. The ideal applications for targeted α-therapy are in treating neoplastic cells in circulation or when cancer cells are present as free-floating cells or spread along compartment walls. This review will provide a brief overview of the most promising radionuclides for targeted α-therapy and compare their relative biological effectiveness (RBE) and normal tissue toxicity.

Keywords: Alpha-particle radiation, radioimmunotherapy, astatine-211, bismuth-213, actinium-225, thorium-227, radiotoxicity, relative biological effectiveness, targeted alpha therapy

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2011
Page: [321 - 328]
Pages: 8
DOI: 10.2174/1874471011104040321
Price: $58

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