Current Drug Discovery Technologies

Vladimir P. Torchilin  
Department of Pharmaceutical Science Center
for Pharmaceutical Biotechnology and Nanomedicine
Northeastern University
Boston, MA 02115
USA

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Inorganic Nanoparticles for Enhanced Photodynamic Cancer Therapy

Author(s): Shih-Hsun Cheng, Leu-Wei Lo.

Abstract:

Photodynamic therapy (PDT) in cancer treatment uses photosensitizers to generate singlet oxygen followed by photoirradiation. The efficacy of PDT is greatly determined by the dosimetry of activation light and the photosensitizer (PS), modulating the photodynamic reaction at depth in diseased tissue. Development of nano-formulated photosensitizer has emerged as a promising field because of the biocompatibility and the accessibility for multi-functionalization of nanoparticles. In this review, we summarize the contemporary progress in use of inorganic nanoparticles for improvement of PDT in cancer therapeutics.

Keywords: Photodynamic therapy (PDT), photosensitizer (PS), nanodelivery, hydrophobic, Silica nanoparticles, Superparamagnetic iron oxide, Quantum dots, photothermal therapy, Multifunctional nanoparticles, hyperthermia

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2011
Page: [269 - 276]
Pages: 8
DOI: 10.2174/157016311796798982
Price: $58