Targeting Interleukin-1β for Pain

Author(s): Sivaram Pillarisetti.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 10 , Issue 5 , 2011

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Abstract:

Interleukin-1β (IL-1β) has been implicated in many inflammatory and autoimmune diseases. Its role in pain, however, is under-appreciated. This may in part be due to the challenges involved in approaching the target from a therapeutic stand point. The scope of this brief review is to understand the direct and indirect roles of IL-1β in contributing to different pain states including inflammatory and neuropathic pain, and discuss approaches to block IL-1β production or IL-1 interactions.

Keywords: Interleukin-1, inflammation, pain, neuropathy, analgesic, hyperalgesia, P2X7, Spinal Nerve Ligation, Complex Regional Pain Syndrome, XOMA

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Article Details

VOLUME: 10
ISSUE: 5
Year: 2011
Page: [571 - 575]
Pages: 5
DOI: 10.2174/187152711796234998
Price: $58

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