The Phage Display Technique: Advantages and Recent Patents

Author(s): Sintia Silva de Almeida, Aryane Aparecida C. Magalhaes, Siomar de Castro Soares, Meritxell Zurita-Turk, Luiz Ricardo Goulart, Anderson Miyoshi, Vasco Azevedo.

Journal Name:Recent Patents on DNA & Gene Sequences (DIscontinued)

Volume 5 , Issue 2 , 2011

Abstract:

Phage display technology has advanced considerably since its inception and the number of research projects using this technique is constantly increasing, generating numerous antibody and antigen libraries. These libraries, besides expediting library screening, improving selection methods and allowing evaluation of novel applications, have great potential for the development of new vaccines, drugs and diagnosis tests. Consequently, patent registries for the protection of these sequences are essential.

Keywords: Phage display, peptide, antibody library, vaccine, patents, Nonribosomal peptides (NRPs), Epitopes, linear mapping, chain atoms, overlapping segments, Mutations of amino acids, ribosome display tecnique, stoichiometric quantity, filamentous phage, hybridoma technology, protein complexes, chemical cross-linking

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Article Details

VOLUME: 5
ISSUE: 2
Year: 2011
Page: [136 - 148]
Pages: 13
DOI: 10.2174/187221511796392060
Price: $100