Recent Patents on the Synthesis and Application of Silica Nanoparticles for Drug Delivery
Maria Lucia Foglia, Gisela Solange Alvarez, Paolo Nicolas Catalano, Andrea Mathilde Mebert, Luis Eduardo Diaz, Thibaud Coradin and Martin Federico Desimone
Affiliation: IQUIMEFA-CONICET.Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junín 956 Piso 3°, (1113) Ciudad Autonoma de Buenos Aires, Argentina.
Keywords: Drug delivery, controlled release, hollow silica nanoparticles, nanoparticles, silica, silica aerogels, targeted delivery, synthetic polymer, lower toxic effects, fabricate, biodegradability, polymorphonuclear leukocytes, porosity change, HSNP, TEOS
Drug delivery systems are designed to improve therapy efficacy as well as patient compliance. This could be accomplished by specifically targeting a medication intact to its active site, therefore reducing side-effects and enabling high local drug concentrations. Silica nanoparticles have gained ground in the biomedical field for their biocompatibility and biodegradability, being themselves inert and stable, thus enabling a variety of formulation designs for application in the pharmaceutical industry. This paper is a review of the recent patents on the applications of silica nanoparticles for drug delivery and their preparation. The review will focus on the different techniques available to obtain silica nanoparticles with variable morphology and their drug targeting applications, providing an overview of silica particles synthesis described in the literature.
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