Human Apurinic/Apyrimidinic Endonuclease (APE1): An Emerging Anti-Cancer Biomarker
Raghav Murali-Ganesh, Rishi Malhotra, Christina J. Perry and Srinivasan Madhusudan
Affiliation: Academic Unit of Oncology,School of Molecular Medical Sciences, University of Nottingham,Nottingham University Hospitals, Nottingham, UK.
Human Apurinic/apyrimidinic Endonuclease 1 (APE1) is a key multifunctional protein essential for DNA base excision repair pathway (BER) involved in the repair of DNA base damage caused by alkylating damage and ionising radiation. In preclinical studies, APE1 depletion enhances cytotoxicity of therapeutic agents. Over-expression of APE1 is frequently seen in human tumours and may have prognostic/predictive significance in patients. Preclinical and clinical studies suggest that APE1 is a viable anticancer drug target. In this review, we summarize relevant patents and recent studies that confirm that APE1 is an emerging biomarker, and a promising therapeutic target in cancer.
Keywords: Cancer, human AP endonuclease 1, APE1, predictive marker, prognostic marker, small molecule inhibitors, AP ENDONUCLEASE, APE1 EXPRESSION, ANTI-CANCER DRUG TARGET, DNA repair domain inhibitors, Chemotherapy, bromodeoxyuridine, proopiomelanocortin
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