HIV Infection Induces Morphometrical Changes on the Oral (Buccal Mucosa and Tongue) Epithelial Cells

Author(s): Adriane Bastos Pompermayer, Francisca Berenice Dias Gil, Beatriz Helena Sottile Franca, Maria Angela Naval Machado, Paula Cristina Trevilatto, Angela Fernandes, Antonio Adilson Soares de Lima.

Journal Name: Current HIV Research

Volume 9 , Issue 1 , 2011

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Abstract:

The aim of this study was to assess morphological and morphometrical alterations of oral squamous epithelial cells in type 1 HIV infected individuals. Oral smears were collected from tongue and buccal mucosa of 30 HIV infected (experimental) and 30 non-infected (control) individuals by liquid-based exfoliative cytology. The cells were morphologically analyzed and the nuclear area (NA), the cytoplasmic area (CA) and the nucleus-to-cytoplasm area ratio (NA/CA) were calculated. No morphological differences were found between the groups. The mean values of CA were decreased in tongue (P.00006) and buccal mucosa (P=.00242) in HIV infected individual, while mean values of NA were increased (P=.00308 and .00095, respectively) in the same group. NA/CA ratio for experimental group was increased in both collected places, with P=.00001 (tongue) and P=.00000 (buccal mucosa). This study revealed that HIV infection was able to induce morphometrical changes on the oral epithelial cells.

Keywords: Exfoliative cytology, HIV, oral mucosa, oral squamous epithelium, immunodeficiency virus, retrovirus, syndrome, immunosuppression, pathogenic, candidosis, Kaposi's sarcoma, oral sex, breast-feeding, keratinocytes, cytomorphologic, blood glucose levels, erythrocyte sedimentation rate, tobacco, mucosa, enzyme, marital, oral liquid-based, cytology, debris, bacteria, squamous epithelial cells, microscopy, binocular, parabasal cells, Fisher's exact test, homogeneity, inflammatory, biopsy, anemia, oral ulceration xerostomia dysgeusis, multiform erythema, lichenoid reaction, hybridiation, immunohistochemisty, dose-dependent, neoplastic, keratinization process, oral epithelium

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2011
Page: [11 - 16]
Pages: 6
DOI: 10.2174/157016211794582678

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