Current HIV Research

Charles Wood  
University of Nebraska
Lincoln, NE


A RhoA-Derived Peptide Inhibits Human Immunodeficiency Virus-1 Entry In Vitro

Author(s): Maciej Maselko, Casey Ward and Manoj Pastey

Affiliation: 210 Dryden Hall, Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon 97331, USA.

Keywords: Antiviral, HIV-1, Peptides, RhoA


RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA 77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides.

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Article Details

Page: [1 - 5]
Pages: 5
DOI: 10.2174/157016211794582605