The Diagnostic and Therapeutic Importance of Human Growth Hormone Isoforms
Marina Mara de Jesus Romero-Prado and Noa Beatriz Martin-Cofreces
Affiliation: Unidad de Investigacion Cardiovascular, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, C.P. 44340, Jalisco. Mexico.
Keywords: Growth hormone isoforms, modified growth hormone, growth hormone-related peptides, growth hormone detection, acetylable chromatin, coactivator complexes, GH-N promoter, proximal promoter regions, Locus Control Region (LCR), peripheral blood monocyte cells (PBMCs), hGH-N polypeptides, disulfide bridges, transgenic mice, dimerization, acid-labile subunit
The study of human growth hormone isoforms has conduced to the elaboration of patents related to very important items: codifying and regulatory sequences, production of the protein at large-scale, modifications to prolong half-life as monomer, dimer and fusion protein for treatments directed to growth-associated diseases. The designed methodologies directed to the identification and quantification of hGH are beside the formers establishing very important basis of patented sources that can be used for a specific and opportune diagnosis and treatment of biological abnormalities or undesirable effects when these growth hormones are involved.
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