The Diagnostic and Therapeutic Importance of Human Growth Hormone Isoforms
Marina Mara de Jesus Romero-Prado and Noa Beatriz Martin-Cofreces
Affiliation: Unidad de Investigacion Cardiovascular, Departamento de Fisiologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, C.P. 44340, Jalisco. Mexico.
The study of human growth hormone isoforms has conduced to the elaboration of patents related to very important items: codifying and regulatory sequences, production of the protein at large-scale, modifications to prolong half-life as monomer, dimer and fusion protein for treatments directed to growth-associated diseases. The designed methodologies directed to the identification and quantification of hGH are beside the formers establishing very important basis of patented sources that can be used for a specific and opportune diagnosis and treatment of biological abnormalities or undesirable effects when these growth hormones are involved.
Keywords: Growth hormone isoforms, modified growth hormone, growth hormone-related peptides, growth hormone detection, acetylable chromatin, coactivator complexes, GH-N promoter, proximal promoter regions, Locus Control Region (LCR), peripheral blood monocyte cells (PBMCs), hGH-N polypeptides, disulfide bridges, transgenic mice, dimerization, acid-labile subunit
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