Therapeutic Approach on AGE-RAGE Interaction and Its Function in Diabetic Inflammation Process

Author(s): Clara A. Veloso, Caroline M.O. Volpe, Cristina L. Carrara, Miriam M. Chaves, Jose A. Nogueira-Machado.

Journal Name: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Under Re-organization)

Volume 4 , Issue 3 , 2010

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Abstract:

Advanced glycation end products (AGEs) are important biochemical compounds found in diabetes mellitus and are likely to be associated with an inflammatory process. Within the vessel wall, AGEs may interact with specific receptors to modulate a large number of cellular properties by activating several signaling pathways. One of these receptors is called “receptor for AGE” (RAGE). The AGE-RAGE interactions enhance transcription genes encoding for cytokines, growth factors, adhesive molecules and increased classical acute phase proteins. Potential preventive and therapeutic approaches toward diabetes and its complications include inhibition of AGE formation, breakage of preformed AGE-proteins crosslink, blockade of AGE-RAGE interactions with RAGE competitors, antibody antagonists and RAGE specific metabolic inhibition. Blockade of AGE-RAGE complex formation suppresses the levels of pro-inflammatory cytokines and growth factors and it may be considered as a target for overcoming diabetic complications. This concise review about AGE-RAGE interaction and diabetes complications discusses pathophysiological mechanisms at a glance. Patents on inhibition of AGE formation, RAGE expression and AGE-RAGE interaction are shown and discussed here.

Keywords: Diabetes, AGEs, RAGE, inflammation, cytokines, patents.

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2010
Page: [241 - 247]
Pages: 7
DOI: 10.2174/1872214811004030241
Price: $58

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