Targeting Interleukin (IL) 5 for Asthma and Hypereosinophilic Diseases

Author(s): Miguel L. Stein, Ariel Munitz.

Journal Name: Recent Patents on Inflammation & Allergy Drug Discovery

Volume 4 , Issue 3 , 2010

Become EABM
Become Reviewer

Abstract:

Although glucocorticosteroids are still the first line of treatment for chronic asthma, over the last two decades great advances have been made in understanding the pathogenesis of asthma that enabled the identification of new therapeutic targets for asthma treatment. The interleukin (IL) 5: eosinophil axis is a hallmark pathway of allergic inflammation that has received much attention. Indeed, IL-5 is known to regulate eosinophil differentiation, proliferation, priming and activation. Therefore, therapeutic agents targeting IL-5 have been generated. In this review we will discuss the effects of IL-5 on eosinophils and outline the signaling mechanism involved in IL-5-mediated effects. Furthermore, recent results from clinical trials targeting IL-5 in asthma and hypereosinophilic syndrome will be discussed and an overview of newly developed patents aimed to target IL-5 will be reviewed.

Keywords: IL-5, eosinophils, asthma, hypereosinophilic syndrome

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 4
ISSUE: 3
Year: 2010
Page: [201 - 209]
Pages: 9
DOI: 10.2174/187221310793564290
Price: $58

Article Metrics

PDF: 4