Ghrelin Receptor Signaling: A Promising Therapeutic Target for Metabolic Syndrome and Cognitive Dysfunction

Author(s): Wei-na Cong, Erin Golden, Nick Pantaleo, Caitlin M. White, Stuart Maudsley, Bronwen Martin.

Journal Name: CNS & Neurological Disorders - Drug Targets

Volume 9 , Issue 5 , 2010

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Abstract:

The neuroendocrine hormone ghrelin is an octanoylated 28-residue peptide that exerts numerous physiological functions. Ghrelin exerts its effects on the body mainly through a highly conserved G protein-coupled receptor known as the growth hormone secretagagogue receptor subtype 1a (GHS-R1a). Ghrelin and GSH-R1a are widely expressed in both peripheral and central tissues/organs, and ghrelin signaling plays a critical role in maintaining energy balance and neuronal health. The multiple orexigenic effects of ghrelin and its receptor have been studied in great detail, and GHS-R1a-mediated ghrelin signaling has long been a promising target for the treatment of metabolic disorders, such as obesity. In addition to its well-characterized metabolic effects, there is also mounting evidence that ghrelin-mediated GHS-R1a signaling exerts neuroprotective effects on the brain. In this review, we will summarize some of the effects of ghrelin-mediated GSH-R1a signaling on peripheral energy balance and cognitive function. We will also discuss the potential pharmacotherapeutic role of GSH-R1a-mediated ghrelin signaling for the treatment of complex neuroendocrine disorders.

Keywords: Cognitive function, energy balance, ghrelin, growth hormone secretagagogue receptor, memory, metabolic disorders, neuroprotection, obesity

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2010
Page: [557 - 563]
Pages: 7
DOI: 10.2174/187152710793361513
Price: $58

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