High Levels of CD57+CD28- T-Cells, Low T-Cell Proliferation and Preferential Expansion of Terminally Differentiated CD4+ T-Cells in HIVElite Controllers

Author(s): Ezequiel Ruiz-Mateos, Sara Ferrando-Martinez, Kawthar Machmach, Pompeyo Viciana, Yolanda M. Pacheco, Nieves Nogales, Miguel Genebat, Manuel Leal.

Journal Name: Current HIV Research

Volume 8 , Issue 6 , 2010

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The study of clinical and demographic characteristics related to virus control and disease progression in patients who spontaneously control HIV vireamia (HIV-controllers) is of major interest. A particular cause of HIV control has not been found and the scenario could be partially explained by special homeostatic and immunological features. In this study, CD57+CD28- phenotype, T-cell activation and levels of proliferating T-cells in elite-controllers were studied in relation to spontaneous virus control. In HIV-controllers, 9% were AIDS-diagnosed and there was a high proportion of women. In elite-controllers, high T-cell CD57+CD28- phenotype and activation levels were found and, interestingly, there was a low proliferation of total and naive T-cells and a high proliferation of the CD4+ TEMRA subset. Low T-cell proliferation and preferential expansion of terminally differentiated effector T-cell subsets could be an important factor for virus control in elite-controllers.

Keywords: HIV, elite-controllers, immunosenescence, activation, CD57+, proliferation, TEMRA

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Article Details

Year: 2010
Page: [471 - 481]
Pages: 11
DOI: 10.2174/157016210793499268
Price: $58

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