Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model

Author(s): Richard A. Peterson , David L. Krull , H. Roger Brown , Mark de Serres .

Journal Name: Drug Metabolism Letters

Volume 4 , Issue 3 , 2010

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Abstract:

Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio® (uPA+/+/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.

Keywords: Chimeric, drug metabolism, hepatocyte, humanized, liver, mouse

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2010
Page: [180 - 184]
Pages: 5
DOI: 10.2174/187231210791698456
Price: $58

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