Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model

Author(s): Richard A. Peterson, David L. Krull, H. Roger Brown, Mark de Serres.

Abstract:

Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio® (uPA+/+/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.

Keywords: Chimeric, drug metabolism, hepatocyte, humanized, liver, mouse

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2010
Page: [180 - 184]
Pages: 5
DOI: 10.2174/187231210791698456
Price: $58