Enzymatic Radiofluorination: Current Status

Author(s): L. Martarello, C. Plisson, A.D. Gee.

Journal Name: Current Radiopharmaceuticals

Volume 3 , Issue 3 , 2010

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Abstract:

This review provides a overview of the use of biocatalysts in fluorine-18 chemistry that have emerged so far. The preparation of the following radiolabelled counpunds are discussed: [18F]5-FDA, [18F]5-FDI, [18F]5-FDR using different enzyme combinations. Nethertheless, the major emphasis is placed on the use of a key enzyme (ie the fluorinase) mediating the reaction between the fluoride ion and S-adenosyl-L-methionine (SAM) to yield the natural product 5- fluoro-5-deoxyadenosine (5-FDA) and the subsequent enzymatic conversion of 5-FDA into 5-FDI and 5-FDR.

Keywords: Biocatolyst, fluorine-18, 5'-FDA, 5'-FDI, 5-FDR

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2010
Page: [243 - 247]
Pages: 5
DOI: 10.2174/1874471011003030243
Price: $58

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