In order to perform nucleophilic reactions of no-carrier-added [18F]fluoride also with arenes of high electron density an electrophilic center must be generated. This can be achieved by electrochemistry, decomposition of aryl-diazo-compounds, and use of aryl-iodonium compounds. Here, some general features and the application of those methods are described.
Keywords: Fluorine-18, radiofluorination, electron rich arenes, iodonium compounds, diazonium compounds, electrochemistry
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