Direct Nucleophilic 18F-Fluorination of Electron Rich Arenes: Present Limits of No-Carrier-Added Reactions

Author(s): Heinz H. Coenen, Johannes Ermert.

Journal Name: Current Radiopharmaceuticals

Volume 3 , Issue 3 , 2010

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In order to perform nucleophilic reactions of no-carrier-added [18F]fluoride also with arenes of high electron density an electrophilic center must be generated. This can be achieved by electrochemistry, decomposition of aryl-diazo-compounds, and use of aryl-iodonium compounds. Here, some general features and the application of those methods are described.

Keywords: Fluorine-18, radiofluorination, electron rich arenes, iodonium compounds, diazonium compounds, electrochemistry

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Article Details

Year: 2010
Page: [163 - 173]
Pages: 11
DOI: 10.2174/1874471011003030163
Price: $58

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