Abstract
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are fatal neurodegenerative disorders of humans and animals caused by conformational conversion of a normal host glycoprotein (PrPC) into an infectious isoform (PrPSc). Whereas the mechanism of PrPSc formation and its infectivity are the subject of intensive research, the exact physiological function of PrPC and the mechanism of neurotoxicity are still unknown. Since prion infections are not limited to a monofunctional event, the PrPC/PrPSc conversion, this review will focus on recent insights into the biology of the prion protein uncovered by proteomic approaches. Recent neuroproteomic studies on the protein profile modifications associated with chronic prion infection in cell systems depicted the co-occurring biochemical abnormalities which are the basis of the prion-induced neuronal death and comprise targets for curative drugs. The involvement of other pathways in prion infectivity opens new insights into understanding of the mechanism of cellular toxicity at the molecular level. This can provide further perspectives for identification of novel therapeutic targets and also allows an integrated paradigm in the prion conversion/toxicity biology.
Keywords: Prion, neurodegeneration, transmissible spongiform encephalopathies, proteomics, mass spectrometry
Current Proteomics
Title: An Update on Prion Biology and Proteomics
Volume: 7 Issue: 1
Author(s): A. R. Roostaee, M. H. Roostaee and X. Roucou
Affiliation:
Keywords: Prion, neurodegeneration, transmissible spongiform encephalopathies, proteomics, mass spectrometry
Abstract: Prion diseases, or transmissible spongiform encephalopathies (TSEs), are fatal neurodegenerative disorders of humans and animals caused by conformational conversion of a normal host glycoprotein (PrPC) into an infectious isoform (PrPSc). Whereas the mechanism of PrPSc formation and its infectivity are the subject of intensive research, the exact physiological function of PrPC and the mechanism of neurotoxicity are still unknown. Since prion infections are not limited to a monofunctional event, the PrPC/PrPSc conversion, this review will focus on recent insights into the biology of the prion protein uncovered by proteomic approaches. Recent neuroproteomic studies on the protein profile modifications associated with chronic prion infection in cell systems depicted the co-occurring biochemical abnormalities which are the basis of the prion-induced neuronal death and comprise targets for curative drugs. The involvement of other pathways in prion infectivity opens new insights into understanding of the mechanism of cellular toxicity at the molecular level. This can provide further perspectives for identification of novel therapeutic targets and also allows an integrated paradigm in the prion conversion/toxicity biology.
Export Options
About this article
Cite this article as:
Roostaee R. A., Roostaee H. M. and Roucou X., An Update on Prion Biology and Proteomics, Current Proteomics 2010; 7 (1) . https://dx.doi.org/10.2174/157016410790979644
DOI https://dx.doi.org/10.2174/157016410790979644 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Oxidative Stress Mechanisms and Potential Therapeutic Modalities in Alzheimer Disease
Medicinal Chemistry Reviews - Online (Discontinued) Serum Starvation Induces BACE1 Processing and Secretion
Current Alzheimer Research Vascular Risk Factors and Neurodegeneration in Ageing Related Dementias: Alzheimer’s Disease and Vascular Dementia
Current Alzheimer Research Molecular Therapy Intervention Prospects in Prostate Cancer
Current Pharmaceutical Design Reorganizing Metals: the Use of Chelating Compounds as Potential Therapies for Metal-Related Neurodegenerative Disease
Current Topics in Medicinal Chemistry Role of Autophagy in Parkinson’s Disease
Current Medicinal Chemistry The Classic Basic Protein of Myelin – Conserved Structural Motifs and the Dynamic Molecular Barcode Involved in Membrane Adhesion and Protein-Protein Interactions
Current Protein & Peptide Science Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 Inhibitor: Plausible Lead for Alzheimer’s Disease
Medicinal Chemistry Clinical Applications of Positron Emission Tomography (PET) Imaging in Medicine: Oncology, Brain Diseases and Cardiology
Current Radiopharmaceuticals Selective Modulator of Cannabinoid Receptor Type 2 Reduces Memory Impairment and Infarct Size During Cerebral Hypoperfusion and Vascular Dementia
Current Neurovascular Research Oxidative RNA Damage and Neurodegeneration
Current Medicinal Chemistry Neurotoxic and Neuroactive Compounds from Cnidaria: Five Decades of Research….and More
Central Nervous System Agents in Medicinal Chemistry Connecting Parkinsons Disease and Drug Addiction: Common Players Reveal Unexpected Disease Connections and Novel Therapeutic Approaches
Current Pharmaceutical Design Inhibitors of Cyclin Dependent Kinases: Useful Targets for Cancer Treatment
Current Cancer Drug Targets Roles of TRAF6 in Central Nervous System
Current Neuropharmacology Targeted Drug Delivery in Brain Tumors-nanochemistry Applications and Advances
Current Topics in Medicinal Chemistry The Mitochondrial Unfolded Protein Response: Role in Cellular Homeostasis and Disease
Current Molecular Medicine “Metabolic Aspects” In Inflammatory Bowel Diseases
Current Drug Delivery Tetracyclines: Drugs with Huge Therapeutic Potential
Mini-Reviews in Medicinal Chemistry Potential Therapeutic Relevance of Adenosine A2B and A2A Receptors in the Central Nervous System
CNS & Neurological Disorders - Drug Targets