Abstract
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are fatal neurodegenerative disorders of humans and animals caused by conformational conversion of a normal host glycoprotein (PrPC) into an infectious isoform (PrPSc). Whereas the mechanism of PrPSc formation and its infectivity are the subject of intensive research, the exact physiological function of PrPC and the mechanism of neurotoxicity are still unknown. Since prion infections are not limited to a monofunctional event, the PrPC/PrPSc conversion, this review will focus on recent insights into the biology of the prion protein uncovered by proteomic approaches. Recent neuroproteomic studies on the protein profile modifications associated with chronic prion infection in cell systems depicted the co-occurring biochemical abnormalities which are the basis of the prion-induced neuronal death and comprise targets for curative drugs. The involvement of other pathways in prion infectivity opens new insights into understanding of the mechanism of cellular toxicity at the molecular level. This can provide further perspectives for identification of novel therapeutic targets and also allows an integrated paradigm in the prion conversion/toxicity biology.
Keywords: Prion, neurodegeneration, transmissible spongiform encephalopathies, proteomics, mass spectrometry
Current Proteomics
Title: An Update on Prion Biology and Proteomics
Volume: 7 Issue: 1
Author(s): A. R. Roostaee, M. H. Roostaee and X. Roucou
Affiliation:
Keywords: Prion, neurodegeneration, transmissible spongiform encephalopathies, proteomics, mass spectrometry
Abstract: Prion diseases, or transmissible spongiform encephalopathies (TSEs), are fatal neurodegenerative disorders of humans and animals caused by conformational conversion of a normal host glycoprotein (PrPC) into an infectious isoform (PrPSc). Whereas the mechanism of PrPSc formation and its infectivity are the subject of intensive research, the exact physiological function of PrPC and the mechanism of neurotoxicity are still unknown. Since prion infections are not limited to a monofunctional event, the PrPC/PrPSc conversion, this review will focus on recent insights into the biology of the prion protein uncovered by proteomic approaches. Recent neuroproteomic studies on the protein profile modifications associated with chronic prion infection in cell systems depicted the co-occurring biochemical abnormalities which are the basis of the prion-induced neuronal death and comprise targets for curative drugs. The involvement of other pathways in prion infectivity opens new insights into understanding of the mechanism of cellular toxicity at the molecular level. This can provide further perspectives for identification of novel therapeutic targets and also allows an integrated paradigm in the prion conversion/toxicity biology.
Export Options
About this article
Cite this article as:
Roostaee R. A., Roostaee H. M. and Roucou X., An Update on Prion Biology and Proteomics, Current Proteomics 2010; 7 (1) . https://dx.doi.org/10.2174/157016410790979644
DOI https://dx.doi.org/10.2174/157016410790979644 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Function of Tyrosine Hydroxylase in the Normal and Parkinsonian Brain
CNS & Neurological Disorders - Drug Targets Antioxidant Capacities of Flavones and Benefits in Oxidative-Stress Related Diseases
Current Topics in Medicinal Chemistry Inhibition of Transcription Factors by Plant-Derived Compounds and their Implications in Inflammation and Cancer
Current Pharmaceutical Design High Throughput Screening for Neurodegeneration and Complex Disease Phenotypes
Combinatorial Chemistry & High Throughput Screening Antioxidant Properties of Melatonin and its Potential Action in Diseases
Current Topics in Medicinal Chemistry Editorial [Hot Topic: Bringing Drugs Into the Injured Brain and Keeping Them There (Executive Guest Editors: Dirk M. Hermann and Pauline Patak)]
Current Pharmaceutical Design Treatment Possibilities for Psychosis in Parkinson's Disease with An Emphasis on the Newly Approved Drug: Pimavanserin
CNS & Neurological Disorders - Drug Targets Mitochondrial Dysfunction and Alzheimers Disease
Current Alzheimer Research Dietary Lipids and Alzheimer’s Disease
Current Alzheimer Research Autoimmunity and Frontotemporal Dementia
Current Alzheimer Research Current Approaches for the Treatment with Thyroid Hormone Analogs
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Is rTMS an Effective Therapeutic Strategy that Can Be Used to Treat Parkinson's Disease?
CNS & Neurological Disorders - Drug Targets Pharmacophore and QSAR Modeling of Neuronal Nitric Oxide Synthase Ligands and Subsequent Validation and In Silico Search for New Scaffolds
Medicinal Chemistry Clinical Uses of Melatonin: Evaluation of Human Trials
Current Medicinal Chemistry Alzheimer's Disease and Natural Products: Future Regimens Emerging from Nature
Current Topics in Medicinal Chemistry Targeting Astrocytes for Treatment in Amyotrophic Lateral Sclerosis
Current Pharmaceutical Design Coenzyme Q10 and Neurological Diseases: An Update
Letters in Drug Design & Discovery Cerebroprotective Functions of HO-2
Current Pharmaceutical Design Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid β-Derived Neurotoxins
CNS & Neurological Disorders - Drug Targets Biphasic Mechanisms of Neurovascular Unit Injury and Protection in CNS Diseases
CNS & Neurological Disorders - Drug Targets