Drug Metabolism Letters

Zhiyang Zhao
Amgen
Cambridge, MA
USA

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Nandrolone Decanoate Enhances the Activities of Cholanthrene Induced Glutathione-s-Transferase in Liver Tissue of Albino Mice

Author(s): Biswajit Kumar Acharjee, Rita Mahanta, Aparajita Borkotoky.

Abstract:

A concrete study is still fragmentary to correlate the effect of Nandrolone decanoate, a anabolic steroid, on the cholanthrene induced Glutathione-s-transferases (GST) activities in liver tissues. Administration of Nandrolone and 3- Methylcholanthrene in alone and combination is found to increase the activity of hepatic GST activity significantly (p < 0.01) suggesting Nandrolone as a potent inducer of GST activity.

Keywords: Xenobiotics metabolism, glutathione-s-transferase, anabolic steroid, nandrolone decanoate, 3-methylcho-lanthrene, liver

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2010
Page: [1 - 6]
Pages: 6
DOI: 10.2174/187231210790980417