Recent Patents on Drug Delivery & Formulation

Ryan F. Donnelly
School of Pharmacy
Queen's University Belfast
Belfast
UK

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Properties and Clinical Development of a Novel Coating Technology: The poly[bis(trifluoroethoxy)phosphazene]

Author(s): Davide Capodanno and Corrado Tamburino

Affiliation: Cardiology Department, Ferrarotto Hospital, via Citelli 6, 95124 Catania, Italy.

Keywords: Polymer, coating, stent

Abstract:

Ultrapure poly[bis(trifluoroethoxy)phosphazene] is a novel biocompatible, anti-inflammatory, antithrombogenic polymer which has the potential to cover stent devices without elution of a cell cycle inhibiting drug. The properties of polyphosphazene are likely to extend its use to a broad array of promising applications. This article reviews the features of the polymer and some recent patents related to use of poly[bis(trifluoroethoxy)phosphazene] in coating, its relevance as compared to other polymers, current evidence on pre-clinical and clinical performance, and future perspectives.

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Article Details

VOLUME: 4
ISSUE: 1
Page: [18 - 22]
Pages: 5
DOI: 10.2174/187221110789957264