Recent Patents on Inflammation & Allergy Drug Discovery

Back

Topical Use of Sucralfate in Epithelial Wound Healing: Clinical Evidence and Molecular Mechanisms of Action

Author(s): Laura Masuelli, Giovanni Tumino, Mario Turriziani, Andrea Modesti and Roberto Bei

Affiliation: Department of Experimental Medicine and Biochemical Sciences, Faculty of Medicine, University of Rome ‘Tor Vergata’, Via Montpellier 1, 00133 Rome, Italy.

Keywords: Sucralfate, topical, epithelial wound, healing, growth factors, inflammation

Abstract:

Sucralfate is a basic aluminium salt of sucrose octasulphate which was orally employed for prevention and treatment of several gastrointestinal diseases including gastroesophageal reflux, gastric and duodenal ulcer. Recent studies have employed sucralfate as a topical drug for the healing of several types of epithelial wounds such as ulcers, inflammatory dermatitis, mucositis and burn wounds. Epithelial wound healing is a well orchestrated process involving hemostasis, inflammatory reaction, cell proliferation and tissue remodeling which leads to granulation tissue development and filling of the wound space. This report will review clinical evidence on the use of topical sucralfate for the management of epithelial lesions and deal with the current knowledge on the molecular mechanisms of action of this compound towards the epithelial wound healing process and will also discuss relevant patents.

Reprint ePrint Rights & PermissionsPrintExport

Article Details

VOLUME: 4
ISSUE: 1
Page: [25 - 36]
Pages: 12
DOI: 10.2174/187221310789895649