CNS & Neurological Disorders - Drug Targets

(Formerly Current Drug Targets - CNS & Neurological Disorders)

Stephen D. Skaper  
Department of Pharmaceutical and Pharmacological Sciences
University of Padova
Padova
Italy

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Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes

Author(s): Paula I. Moreira, Sandra M. Cardoso, Claudia M. Pereira, Maria S. Santos, Catarina R. Oliveira.

Abstract:

Due to the increasing number of data demonstrating a connection between diabetes and Alzheimers disease (AD), efforts have been developed to elucidate the exact mechanism(s) underlying this connection. Although both disorders possess several overlapping features, mitochondrial dysfunction is one of the most relevant rendering mitochondria an important target of scientific research. This review discusses clinical and biochemical features shared by AD and diabetes, giving special attention to the involvement of mitochondria. The realization that mitochondria are at the intersection of cells life and death has made them a promising target for drug discovery and therapeutic interventions. Here we also discuss in vitro, in vivo and clinical studies that examined the effect of mitochondria-directed therapeutics particularly mitochondrial target antioxidants and Szeto-Schiller peptides.

Keywords: Alzheimer's disease, antioxidants, diabetes, mitochondria, MitoQ, MitoVitE, SS peptides

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Article Details

VOLUME: 8
ISSUE: 6
Year: 2009
Page: [492 - 511]
Pages: 20
DOI: 10.2174/187152709789824651
Price: $58